Keywords: Clopidogrel activation.svg Clopidogrel top left being activated The active metabolite top right has Z configuration at the double bond C3 “C16 and possibly R configuration at the newly asymmetric C4 The first step is a cytochrome P450 mediated oxidation; the two structures at the bottom are tautomer s of each other; and the final step is a hydrolysis own based on cite journal Pereillo JM Maftouh M Andrieu A Uzabiaga MF Fedeli O Savi P Pascal M Herbert JM Maffrand JP Picard C 2002 Structure and stereochemistry of the active metabolite of clopidogrel Drug Metab Dispos 30 11 1288 “95 12386137 10 1124/dmd 30 11 1288 http //dmd aspetjournals org/cgi/reprint/30/11/1288 pdf Anypodetos 2011-12-24 BKchem 001 -check Clopidogrel Metabolic pathways Cc-zero |