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| Keywords: Hemoglobinopathies-Slicing-the-Gordian-Knot-of-Plasmodium-falciparum-Malaria-Pathogenesis-ppat.1003327.g001.jpg en A Restriction of red blood cell RBC invasion or intraerythrocytic growth thereby suppressing parasite densities in vivo; B interference with parasite-derived mediators of pathogenesis including those involved in the binding of parasite-infected RBCs iRBCs to extracellular host receptors; C modulation of innate host defenses to favor protective anti-inflammatory responses over those that drive pathogenic pro-inflammatory responses; D enhancement of adaptive cell-mediated and humoral immune responses that clear iRBCs from the blood 2013-05 http //dx doi org/10 1371/journal ppat 1003327 Image file from Cite journal Taylor S Cerami C Fairhurst R Hemoglobinopathies Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis 10 1371/journal ppat 1003327 PLOS Pathogens 2013 23696730 3656091 Taylor S Cerami C Fairhurst R cc-zero Information field Provenance Recitation-bot Human genetics Molecular genetics Adaptive immunity Humoral immunity Immune tolerance Innate immunity Host-pathogen interactions Molecular cell biology Cell types Endothelial cells Cell adhesion Genetics of disease Global health Sickle cell disease Red cells Plasmodium falciparum Parasitic diseases Media from PLOS Pathogens Uploaded with reCitation Bot Uploaded_with reCitation Bot and needing category review | ||||
