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| Keywords: PNN.png en A Perineuronal nets are made of chondroitin sulfate proteoglycans CSPG Here the CSPGs neuroscan veriscan brevican and aggrecan are noncovalently bonded to hyaluron Other associations occur between other CSPGs through tenascin T triangles Tenascin in turn binds to CS glycosaminoglycans red lines as well as cell surface CSPGs Phosphacan can also bind to cell surface receptors such as NCAM B Application of chondroitinase ABC ChABC degrades all the CS glycosaminoglycans red lines as well as hyaluronan pink line causing major disruptions in the structure of the perineuronal net These disruptions may allow axons to penetrate the vacated space and allow restoration of neuronal plasticity own Bbari3 2010-11-29 Neuronal circuits Chondroitin ABC lyase I N-terminal domain | ||||
