Keywords: Sickle cell gene under selection.png en The calculated rate at which the frequency of a newly mutated sickle-cell gene will increase in a population exposed to intense malarial selection The change over generations in the sickle-cell heterozygote Aa + homozygote AA frequency in the adult population that would occur from a low level recent mutation or a high level unlikely founder event in a small population when the fitnesses of the normal homozygote sickle-cell heterozygote and sickle-cell homozygote are 0 95 1 19 and 0 30 respectively Based on data published in Allison AC 1955 Aspects of polymorphism in man Cold Spring Harb Symp Quant Biol 20 239-251 own TimVickers Sickle-cell anemia Population genetics |